Publications
Search
[2016]
Peroxygenase-catalyzed oxyfunctionalization reactions promoted by the complete oxidation of methanol
Ni Y, Fernandez-Fueyo E, Baraibar AG, Ullrich R, Hofrichter M, Yanase H, Alcalde M, van Berkel WJ, Hollmann F
Angew. Chem. Int. Ed., 55: 798-801
Peroxygenases catalyze a broad range of (stereo)selective oxyfunctionalization reactions. However, to access their full catalytic potential, peroxygenases need a balanced [...]
[2015]
Steroid hydroxylation by basidiomycete peroxygenases: A combined experimental and computational study
Babot ED, del Río JC, Cañellas M, Sancho F, Lucas F, Guallar V, Kalum L, Lund H, Gröbe G, Scheibner K, Ullrich R, Hofrichter M, Martínez AT, Gutiérrez A
Appl. Environ. Microbiol., 81: 4130-4142, 10.1128/AEM.00660-15
The goal of this study is the selective oxyfunctionalization of steroids under mild and environmentally-friendly conditions using fungal enzymes. With this purpose, peroxygenases [...]
[2015]
One-pot synthesis of human metabolites of SAR548304 by fungal peroxygenases
Kiebist J, Holla W, Heidrich J, Poraj-Kobielska M, Sandvoss M, Simonis R, Gröbe G, Atzrodt J, Hofrichter M, Scheibner K
Bioorgan. Med. Chem., 23: 4324-4332
Unspecific peroxygenases (UPOs, EC 1.11.2.1) have proved to be stable oxygen-transferring biocatalysts for H2O2-dependent transformation of pharmaceuticals. We have applied [...]
[2014]
5-Hydroxymethylfurfural conversion by fungal aryl-alcohol oxidase and unspecific peroxygenase
Carro J, Ferreira P, Rodríguez L, Prieto A, Serrano A, Balcells B, Ardá A, Jiménez-Barbero J, Gutiérrez A, Ullrich R, Hofrichter M, Martínez AT
FEBS J., 282: 3218-3229
Oxidative conversion of 5-hydroxymethylfurfural (HMF) is of biotechnological interest for the production of renewable (lignocellulose based) platform chemicals, such as 2,5-furandicarboxylic [...]